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Electrogenerated chemiluminescence of novel TiO₂/CdS nanocomposites for sensitive assays of cancer cells
- Huang, Tingyu, Jie, Guifen
- Analytical biochemistry 2013 v.442 no.1 pp. 34-39
- biosensors, cell membranes, chemiluminescence, folic acid, nanocomposites, neoplasm cells
- A novel TiO₂/CdS nanocomposite was prepared and used to fabricate an electrochemiluminescence (ECL) biosensor for the detection of cancer cells for the first time. The nanocomposite exhibited a strong cathodic ECL signal. Folic acid for targeting cell membranes was bound to a TiO₂/CdS/3-aminopropyltriethoxysilane film, and specific recognition of folic acid to targeting cells was achieved, leading to a significant decrease in ECL intensity. The decrease in ECL signal was logarithmically related to the cell concentration in the range of 150–9600cellsmL⁻¹. The ECL biosensor could provide a sensitive, selective, and convenient approach for early and accurate detection of cancer cells.