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Analgesic effects of the ethanolic extract from Magnolia ovata (Magnoliaceae) trunk bark and of N-acetylxylopine, a semi-synthetic analogue of xylopine

Author:
Mori, Lídia Sayuri, Boller, Shirley, Kassuya, Cândida Aparecida Leite, Stefanello, Maria Élida Alves, Zampronio, Aleksander Roberto
Source:
Phytomedicine 2011 v.18 no.2-3 pp. 143-147
ISSN:
0944-7113
Subject:
Magnolia, acetic acid, analgesic effect, bark, dose response, inflammation, mice, models, nociception, oral administration, pain, plant extracts
Abstract:
This study investigated the antinociceptive effects of the ethanolic extract (EEMO) obtained from Magnolia ovata (A.St.-Hil.) Spreng and N-acetylxylopine (AXyl), a stable derivative of xylopine in different models of nociception. The EEMO and AXyl inhibited the nociception induced by acetic acid in mice, in a dose-dependent manner with a maximal inhibition of 91±9% and 50±11%, respectively. Oral administration of EEMO or AXyl also significantly inhibited the inflammatory phase of formalin-induced nociception with maximal reduction of 87±3.9% and 71±10%, respectively. Confirming the effectiveness of the extract and the isolated compound in inflammatory responses, EEMO or AXyl inhibited carrageenan-induced mechanical allodynia with percentage of inhibition of 40±6% for EEMO and 82±8% for AXyl. Intraplantar injection of AXyl in the ipsilateral paw, but not in the contralateral paw, also reduced carrageenan-induced mechanical allodynia in mice. The response of the animals for maximal doses tested of EEMO and AXyl in the hot-plate or rota-rod models were not altered. These results show that the extract from M. ovata and the stable derivative AXyl possess analgesic properties towards inflammatory pain acting on peripheral sites.
Agid:
838704