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Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components

Sundaram, Ramalingam, Naresh, Rajendran, Shanthi, Palanivelu, Sachdanandam, Panchanatham
Phytomedicine 2012 v.19 no.3-4 pp. 211-216
Vitex negundo, animal disease models, blood glucose, diabetes mellitus, fucose, glibenclamide, glucosides, glycemic effect, glycoproteins, hexosamines, hyperglycemia, hypoglycemic agents, insulin, iridoid glycosides, leaves, metabolism, oral administration, rats, sialic acids
The aim of present study was to isolate an iridoid glucoside from the leaves of Vitex negundo and evaluates its effects on dearrangement in plasma and tissues glycoprotein components in streptozotocin-induced diabetic rats. The levels of blood glucose, plasma and tissues glycoproteins such as hexose, hexosamine, fucose and sialic acid were significantly increased whereas plasma insulin levels were significantly decreased in diabetic rats. On oral administration of iridoid glucoside at a concentration of 50mg/kg b.w. once daily to diabetic rats for the period of 30days, reversed the above-mentioned hyperglycemia-induced biochemical changes to near normal levels. The anti-hyperglycemic effect of iridoid glucoside was comparable with glibenclamide, a known hypoglycemic drug. Based on the results obtained from the present study, it may be concluded that iridoid glucoside possesses significant productive effect on glycoprotein metabolism in addition to its antidiabetic effect.