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Regio-selective prenylation of flavonoids by plant cell suspension cultures of Cudrania tricuspidata and Morus alba

Author:
Yin, Yunze, Chen, Ridao, Zhang, Dewu, Qiao, Lirui, Li, Jianhua, Wang, Ruishan, Liu, Xiao, Yang, Lin, Xie, Dan, Zou, Jianhua, Wang, Chunmei, Dai, Jungui
Source:
Journal of Molecular Catalysis. B, Enzymatic 2013 v.89 pp. 28-34
ISSN:
1381-1177
Subject:
Maclura tricuspidata, Morus alba, biotransformation, catalytic activity, cell culture, genistein, microsomes
Abstract:
The cell suspension cultures of Cudrania tricuspidata could regio-selectively prenylate chrysin (1) at C-8, while the cell suspension cultures of Morus alba could regio-selectively prenylate genistein (2), sophoricoside (3) and diosmetin (4) at C-6. Eight products (5–12) were isolated, and five of them (8–12) were new compounds. Additionally, the bioconversion of 1–4 using microsomes of the cell cultures was performed, and the results showed that the bioconversion patterns were identical to those using cell cultures. These investigations would provide an approach to the selective prenylation and structural diversification of flavonoids.
Agid:
855178