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Chemo-enzymatic synthesis of optically pure rivastigmine intermediate using alcohol dehydrogenase from baker's yeast

Author:
Sethi, Madhuresh K., Bhandya, Somashekar R., Kumar, Anish, Maddur, Nagaraj, Shukla, Rohit, Jayalakshmi Mittapalli, V.S.N.
Source:
Journal of Molecular Catalysis. B, Enzymatic 2013 v.91 pp. 87-92
ISSN:
1381-1177
Subject:
NAD (coenzyme), alcohol dehydrogenase, bakers yeast, catalytic activity
Abstract:
An efficient and practical synthesis of (S)-rivastigmine intermediate was developed by employing a chemoenzymatic step toward the synthesis of chiral intermediate N-ethyl-N-methyl-carbamic acid-3-(1S-hydroxy-ethyl)-phenyl ester (2) using crude alcohol dehydrogenase from baker's yeast with reduced nucleotide adenosine dinucleotide (NADH) as proton donor has been demonstrated.
Agid:
855225