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Biocatalyzed kinetic resolution of racemic mixtures of chiral α-aminophosphonic acids

Author:
Kozyra, Kinga, Brzezińska-Rodak, Małgorzata, Klimek-Ochab, Magdalena, Żymańczyk-Duda, Ewa
Source:
Journal of Molecular Catalysis. B, Enzymatic 2013 v.91 pp. 32-36
ISSN:
1381-1177
Subject:
Aspergillus niger, Aspergillus parasiticus, Fusarium oxysporum, Talaromyces funiculosus, biotransformation, catalytic activity, enantiomers, fungi, phosphorous acid
Abstract:
Several fungal species namely: Aspergillus niger, Aspergillus parasiticus, Penicillium funiculosum, Trigonopsis variabilis and two different strains of Fusarium oxysporum were tested toward racemic mixtures of following phosphonic acids: 1-amino-2-methylpropanephosphonic acid, 1-aminophenylmethanephosphonic acid and 1-amino-2-phenylethanephosphonic acid. Application of F. oxysporum strain (UW1) allowed obtaining optically pure S-isomer of 1-aminophenylmethanephosphonic acid and R-isomer of 1-amino-2-phenylethanephosphonic acid, whereas biotransformation of racemic mixture of 1-amino-2-methylpropanephosphonic acid with F. oxysporum strain (DSM 12646) cells resulted in obtaining pure enantiomer of R-configuration.
Agid:
855229