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Stereoselective synthesis of aryl γ,δ-unsaturated β-hydroxyesters by ketoreductases
- Dai, Zhipeng, Guillemette, Kate, Green, Thomas K.
- Journal of Molecular Catalysis. B, Enzymatic 2013 v.97 pp. 264-269
- alcohol oxidoreductases, catalytic activity, enantiomers, esters, stereochemistry, synthesis
- The biocatalytic reduction of aryl γ,δ-unsaturated-β-ketoesters was evaluated utilizing 24 different commercially available ketoreductases. In all cases, both (R) and (S)-enantiomers of γ,δ-unsaturated β-hydroxyesters were synthesized by one or more ketoreductases in excellent optical purity and yields.