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Stereoselective synthesis of aryl γ,δ-unsaturated β-hydroxyesters by ketoreductases

Author:
Dai, Zhipeng, Guillemette, Kate, Green, Thomas K.
Source:
Journal of Molecular Catalysis. B, Enzymatic 2013 v.97 pp. 264-269
ISSN:
1381-1177
Subject:
alcohol oxidoreductases, catalytic activity, enantiomers, esters, stereochemistry, synthesis
Abstract:
The biocatalytic reduction of aryl γ,δ-unsaturated-β-ketoesters was evaluated utilizing 24 different commercially available ketoreductases. In all cases, both (R) and (S)-enantiomers of γ,δ-unsaturated β-hydroxyesters were synthesized by one or more ketoreductases in excellent optical purity and yields.
Agid:
855327