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Oxidative Stress in the Liver of Mice Caused by Intraperitoneal Injection with Lanthanoides

Fei, Min, Li, Na, Ze, Yuguan, Liu, Jie, Gong, Xiaolan, Duan, Yanmei, Zhao, Xiaoyang, Wang, Han, Hong, Fashui
Biological trace element research 2011 v.139 no.1 pp. 72-80
abdominal cavity, antioxidants, ascorbate peroxidase, ascorbic acid, catalase, defense mechanisms, glutathione, intraperitoneal injection, liver, mice, oxidative stress, superoxide dismutase
In order to study the mechanisms underlying the effects of lanthanoid (Ln) on the liver, ICR mice were injected with LaCl3, CeCl3, and NdCl3 at a dose of 20 mg/kg BW into the abdominal cavity daily for 14 days. We then examined oxidative stress-mediated responses in the liver. The increase of lipid peroxide in the liver produced by Ln suggested an oxidative attack that was activated by a reduction of antioxidative defense mechanisms as measured by analyzing the activities of superoxide dismutase, catalase, and ascorbate peroxidase, as well as antioxidant levels such as glutathione and ascorbic acid, which were greatest in Ce3+ treatment, medium in Nd3+, and least in La3+. Our results also implied that the oxidative stress in the liver caused by Ln likely is Ce3+ > Nd3+ >La3+, but the mechanisms need to be further studied in future.