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Mercury and selenium in fish and shellfish: Occurrence, bioaccessibility and uptake by Caco-2 cells
- Calatayud, Marta, Devesa, Vicenta, Virseda, Juan Ramón, Barberá, Reyes, Montoro, Rosa, Vélez, Dinoraz
- Food and chemical toxicology 2012 v.50 no.8 pp. 2696-2702
- Xiphias gladius, bioavailability, digestion, fish, food safety, human cell lines, intestinal mucosa, mercury, models, raw seafoods, risk, selenium, shellfish, toxicology, Spain
- This study evaluates Hg and Se concentrations and bioaccessibility (element solubilised after simulated gastrointestinal digestion) in 16 raw seafood species consumed in Spain. The concentrations varied greatly (Hg, 3.8–1621ng/g wet weight, ww; Se, 84–1817ng/g ww). Only one sample of swordfish exceeded the Hg limit permitted in Spain (1mg/kg), and for this sample the Hg/Se molar ratio and Se Health Benefit Value food safety criteria also indicated the presence of a risk. Bioaccessibility of Hg (35–106%) and Se (17–125%) was very variable and the Hg/Se molar ratio in the bioaccessible fraction was less than one for all samples. Transport by Caco-2 cells, an intestinal epithelium model, was also evaluated from the swordfish bioaccessible fraction. Hg and Se transport from the food was less than 14%, and cell retention was much greater for Hg (49–69%) than Se (8–12%).