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Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

Author:
Xu, Xijin, Yekeen, Taofeek Akangbe, Xiao, Qiongna, Wang, Yuangping, Lu, Fangfang, Huo, Xia
Source:
Environmental pollution 2013 v.182 pp. 63-69
ISSN:
0269-7491
Subject:
blood, electronic wastes, fetal development, gas chromatography, growth and development, insulin-like growth factor I, mass spectrometry, messenger RNA, polybrominated diphenyl ethers, polycyclic aromatic hydrocarbons, pregnant women, quantitative polymerase chain reaction, questionnaires, recycling, umbilical cord
Abstract:
Electronic waste recycling produces Polycyclic Aromatic Hydrocarbons (PAHs) and Polybrominated Diphenyl Ethers (PBDEs) which may affect fetal growth and development by altering the insulin-like-growth factor (IGF) system. Questionnaires were administered to pregnant women (Guiyu, an e-waste site, n = 101; control, n = 53), and umbilical cord blood (UCB) and placentas were collected upon delivery. PBDEs and PAHs in UCB and placental IGF-1 and IGFBP-3 mRNA levels were analyzed using GC–MS and real-time PCR, respectively. Infant birth length and Apgar scores were lower in Guiyu. All PAHs (except Fl, Chr, IP, BbF and BP), total 16-PAHs, total/individual PBDEs, placental IGF-1 (median 0.23 vs 0.19; P < 0.05) and IGFBP-3 (median 1.91 vs 0.68; P < 0.001) levels were significantly higher in Guiyu. Spearman correlation showed that BDE-154, BDE-209 and ∑5ring-PAHs positively correlate with IGF-1 while PBDEs, 4 rings and total PAHs correlate with IGFBP-3 expression. Increased placental IGF-1 level might indirectly affect fetal growth and development.
Agid:
867619