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Anti-inflammatory compounds from Monascus pilosus-fermented rice

Author:
Cheng, Ming-Jen, Wu, Ming-Der, Su, Yung-Shun, Chen, Ih-Sheng, Yuan, Gwo-Fang
Source:
Phytochemistry letters 2012 v.5 no.1 pp. 63-67
ISSN:
1874-3900
Subject:
Monascus pilosus, alkaloids, fungi, inhibitory concentration 50, lipopolysaccharides, mutants, nuclear magnetic resonance spectroscopy, pyridines, red yeast rice, rice, spectral analysis, tumor necrosis factor-alpha
Abstract:
Investigation of the 95% ethanolic extract of red yeast rice fermented with the pink mutant of the fungus Monascus pilosus BCRC PK-1 led to the isolation of one new pyridine alkaloid, namely (E)-methyl 4-(2-acetyl-4-oxotridec-1-enyl)-6-propylnicotinate (1), together with 9 known compounds (2–10). Their structures were elucidated on the basis of spectroscopic data, including homo- and heteronuclear correlation NMR experiments (COSY, HSQC and HMBC) and comparison with data reported in the literature. We also evaluated the inhibitory effects of some isolates on the production of tumor necrosis factor (TNF-α) induced by lipopolysaccharide (LPS). Among the isolates, compounds 1 and 2 inhibited TNF-alpha production in U937 cells in vitro, and the IC₅₀ values are 1.52 and 2.56μg/ml, respectively.
Agid:
870633