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Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

Author:
Zhang, Xiao-Qiang, Li, Fu, Zhao, Zhi-Gang, Liu, Xing-Li, Tang, Ya-Xiong, Wang, Ming-Kui
Source:
Phytochemistry letters 2012 v.5 no.4 pp. 721-724
ISSN:
1874-3900
Subject:
Jatropha curcas, X-ray diffraction, bark, cytotoxicity, diterpenoids, human cell lines, neoplasm cells, spectral analysis
Abstract:
Three new diterpenoids, named epi-jatrophol (1), jatrophaldehyde (2) and epi-jatrophaldehyde (3), along with nine known ones (4–12), were isolated from the root bark of Jatropha curcas. The new compounds were identified by spectroscopic data, and their relative configurations were confirmed by X-ray crystallography or chemical methods. The cytotoxic activities of the isolated compounds were evaluated against HEPG2 and LOVO tumor cell lines. Compounds 8, 9 and 10 were found to be cytotoxic toward HEPG2 cells for the first time.
Agid:
870771