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Xanthone derivatives from Aspergillus sydowii, an endophytic fungus from the liverwort Scapania ciliata S. Lac and their immunosuppressive activities

Author:
Song, Xian-Qin, Zhang, Xin, Han, Qiu-Ju, Li, Xiao-Bin, Li, Gang, Li, Rui-Juan, Jiao, Yang, Zhou, Jin-Chuan, Lou, Hong-Xiang
Source:
Phytochemistry letters 2013 v.6 no.3 pp. 318-321
ISSN:
1874-3900
Subject:
Aspergillus, endophytes, fungi, lymphocytes, mice, mosses and liverworts, nuclear magnetic resonance spectroscopy, sulfur, xanthone
Abstract:
Three new xanthone derivatives, including two first reported containing sulfur as natural products: sydoxanthone A (1) and sydoxanthone B (2), and 13-O-acetylsydowinin B (3) were isolated from an endophytic fungus Aspergillus sydowii, occurring in the livewort Scapania ciliata S. Lac, together with seven known biosynthetically related compounds (4–10). Their structures were established primarily by NMR, UV and MS data. In vitro suppression test on the Con A- and LPS-induced proliferations of mouse splenic lymphocytes showed that compounds 7 and 8 displayed moderate immunosuppressive activities.
Agid:
870849