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Porcine intestinal epithelial responses to Campylobacter infection

Author:
Murphy, H., Cogan, T., Hughes, R., Humphrey, T.
Source:
Comparative immunology, microbiology, and infectious diseases 2011 v.34 no.6 pp. 489-495
ISSN:
0147-9571
Subject:
Campylobacter, animal models, diarrhea, innate immunity, intestinal mucosa, piglets
Abstract:
Campylobacter infection is estimated to cause diarrhoea in 1% of the population of developed countries every year, but our understanding of this disease has been hampered by a lack of a suitable animal model. Colostrum-deprived piglets have been suggested as models since they produce similar clinical signs to humans when infected but little information currently exists regarding the response of this species to Campylobacter at cellular and molecular level. This study shows that intestinal epithelial cells from both species respond in a similar manner to Campylobacter infection regarding invasion, induction of innate immune response and effect on barrier function.
Agid:
871731