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In vitro inhibitory effect of oriental melon (Cucumis melo L. var. makuwa Makino) seed on key enzyme linked to type 2 diabetes

Author:
Chen, Lei, Kang, Young-Hwa
Source:
Journal of functional foods 2013 v.5 no.2 pp. 981-986
ISSN:
1756-4646
Subject:
Cucumis melo, alpha-amylase, alpha-glucosidase, ethanol, food industry, functional foods, gas chromatography-mass spectrometry, hexane, in vitro studies, linoleic acid, melons, noninsulin-dependent diabetes mellitus, oleic acid, palmitic acid
Abstract:
As the world’s population continues to increase, the agricultural discards of plant origin have attracted considerable attention for various purposes in the pharmaceutical and food industry. The objective of present study was to evaluate the potential of oriental melon (Cucumis melo L. var. makuwa Makino) seed for management of hyperglycaemia-linked to type 2 diabetes. Ethanol and hexane extracts from oriental melon seed were used to evaluate their inhibitory activities against α-glucosidase and α-amylase. Low phenolic-containing hexane extract exhibited much higher inhibitory activities against α-glucosidase and α-amylase than ethanol extract. The GC–MS result revealed that hexane extract constituted linoleic acid (29.6%), oleic acid (17.3%), and palmitic acid (6.5%). At high concentration, hexane extract exhibited strong inhibitory activities against α-glucosidase (35.3%) and α-amylase (61.8%). These in vitro studies indicated that hexane extract of oriental melon seed could be used as a potent alternative for controlling type 2 diabetes.
Agid:
887442