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Immunoproteasome expression is induced in mesial temporal lobe epilepsy

Author:
Mishto, Michele, Ligorio, Claudia, Bellavista, Elena, Martucci, Morena, Santoro, Aurelia, Giulioni, Marco, Marucci, Gianluca, Franceschi, Claudio
Source:
Biochemical and biophysical research communications 2011 v.408 no.1 pp. 65-70
ISSN:
0006-291X
Subject:
autoimmune diseases, brain, cortex, epilepsy, histopathology, patients
Abstract:
Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease.
Agid:
893853