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Effects of carboxymethyl chitosan on the blood system of rats

Author:
Fu, Dawei, Han, Baoqin, Dong, Wen, Yang, Zhao, Lv, You, Liu, Wanshun
Source:
Biochemical and biophysical research communications 2011 v.408 no.1 pp. 110-114
ISSN:
0006-291X
Subject:
abdominal cavity, biomedical materials, blood, blood viscosity, chemokine CXCL4, chitosan, coagulation, fibrin, fibrinogen, hemostasis, plasminogen, prothrombin, rats, thrombin, viscosity
Abstract:
Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, was extensively studied in the biomedical materials field for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CM-chitosan in the blood system are lacking. In this study CM-chitosan was implanted into the abdominal cavity of rats to determine blood indexes at different times and to evaluate the effects of CM-chitosan on the blood system of rats. Coagulation function was reflected by thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4) indexes; anti-coagulation performance was assessed by the index of antithrombinIII (ATIII); fibrinolytic function was reflected by plasminogen (PLG) and fibrin degradation product (FDP) indexes; and blood viscosity (BV) and plasma viscosity (PV) indexes reflected hemorheology. Results showed that CM-chitosan has no significant effects on the blood system of rats, and provides experimental basis for CM-chitosan to be applied in the field of biomedical materials.
Agid:
893856