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Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway
- Son, Tae Gen, Kawamoto, Elisa M., Yu, Qian-Sheng, Greig, Nigel H., Mattson, Mark P., Camandola, Simonetta
- Biochemical and biophysical research communications 2013 v.433 pp. 602-606
- death, gene expression regulation, genes, neurons, neuroprotective effect, phytopharmaceuticals, plumbagin, stress response
- Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cellular stress response pathway involved in neuroprotection. We previously screened several natural phytochemicals and identified plumbagin as a novel activator of the Nrf2/ARE pathway that can protect neurons against ischemic injury. Here we extended our studies to natural and synthetic derivatives of plumbagin. We found that 5,8-dimethoxy-1,4-naphthoquinone (naphthazarin) is a potent activator of the Nrf2/ARE pathway, up-regulates the expression of Nrf2-driven genes in primary neuronal and glial cultures, and protects neurons against glutamate-induced excitotoxicity.