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PLP-dependent enzymes as potential drug targets for protozoan diseases

Barbara Kappes, Ivo Tews, Alexandra Binter, Peter Macheroux
Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1567-1576
Protozoa, drugs, enzymatic reactions, enzymes, enzymology, parasites, physicochemical properties, pyridoxal phosphate, pyridoxine
The chemical properties of the B₆ vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B₆ dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites. Comparison across a range of these organisms allows insight into the distribution of potential targets, many of which may be of interest in the development of broad range anti-protozoan drugs. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.