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A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Author:
Zhou, Chuncai, Li, Peng, Qi, Xiaobao, Sharif, Abdul Rahim Mohamed, Poon, Yin Fun, Cao, Ye, Chang, Matthew W., Leong, Susanna Su Jan, Chan-Park, Mary B.
Source:
Biomaterials 2011 v.32 no.11 pp. 2704-2712
ISSN:
0142-9612
Subject:
Candida albicans, Escherichia coli, Fusarium solani, Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, anti-infective properties, bacteria, biocompatibility, coatings, erythrocytes, fungi, hemolysis, humans, hydrocolloids, medical equipment
Abstract:
Hydrogels made from epsilon-poly-l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230–1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.
Agid:
903094