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A Gd-doped Mg-Al-LDH/Au nanocomposite for CT/MR bimodal imagings and simultaneous drug delivery

Wang, Lijun, Xing, Huaiyong, Zhang, Shengjian, Ren, Qingguo, Pan, Limin, Zhang, Kun, Bu, Wenbo, Zheng, Xiangpeng, Zhou, Liangping, Peng, Weijun, Hua, Yanqing, Shi, Jianlin
Biomaterials 2013 v.34 no.13 pp. 3390-3401
antineoplastic agents, cytoplasm, cytotoxicity, death, diagnostic techniques, drug carriers, early diagnosis, heparin, image analysis, intravenous injection, magnetic resonance imaging, mice, monitoring, nanocomposites, neoplasm cells, neoplasms
The early diagnosis and simultaneous drug delivery monitored by non-invasive visualization are highly challenging but clinical-relevant for the diagnostics and therapy monitoring of serious diseases such as cancers. Herein, a Gd-doped layered double hydroxide (LDH)/Au nanocomposite has been developed as both a drug carrier and a diagnostic agent. The obtained nanocomposite shows high non-anionic anti-cancer drug DOX loading capacity and an interesting pH-responsive release profile of loaded DOX. The nanocomposite was found to be able to efficiently transport DOX into the cancer cell, release the DOX in the acidic cytoplasm and then cause death of cancer cells. Meanwhile, the nanocomposite demonstrates better in vitro CT and T₁-weighted MR imaging capabilities than the commercial MRI and CT contrast agents and favorable in vivo CT and T₁-weighted MR imaging performance. After being modified with heparin, the nanocomposite also demonstrates effective CT and MR imagings of tumors by intravenous administration in tumor-bearing mice. Furthermore, the nanocomposite shows negligible cytotoxicity and no detectable tissue damage on mice after injection of high dosage of nanocomposite. In conclusion, the synthetic nanocomposite is expected to be a potential theranostic agent for bimodal imagings of cancers and anti-cancer drug delivery as well.