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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
- Salmena, Leonardo, Poliseno, Laura, Tay, Yvonne, Kats, Lev, Pandolfi, Pier Paolo
- Cell 2011 v.146 no.3 pp. 353-358
- humans, microRNA, non-coding RNA, pseudogenes, response elements, transcription (genetics), transcriptome
- Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs “talk” to each other using microRNA response elements (MREs) as letters of a new language. We propose that this “competing endogenous RNA” (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.