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A Tollgate for Typhoid
- Fang, Ferric C., Bäumler, Andreas J.
- Cell 2012 v.151 no.3 pp. 473-475
- Salmonella Typhi, Toll-like receptors, humans, mice, typhoid fever, vaccines
- Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enterica serovar Typhi. Mathur et al. now report that mice lacking Toll-like receptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that promises to speed the development of better vaccines.