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Candida albicans specializations for iron homeostasis: from commensalism to virulence
- Noble, Suzanne M
- Current opinion in microbiology 2013 v.16 no.6 pp. 708-715
- Candida albicans, commensalism, evolution, fungi, homeostasis, hosts, humans, iron, lifestyle, niches, pathogens, toxicity, virulence
- Candida albicans is a fungal commensal-pathogen that persistently associates with its mammalian hosts. Between the commensal and pathogenic lifestyles, this microorganism inhabits host niches that differ markedly in the levels of bioavailable iron. A number of recent studies have exposed C. albicans specializations for acquiring iron from specific host molecules in regions where iron is scarce, while also defending against iron-related toxicity in regions where iron occurs in surfeit. Together, these results point to a central role for iron homeostasis in the evolution of this important human pathogen.