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Control of RNA processing by a large non-coding RNA over-expressed in carcinomas
- Lin, Rui, Roychowdhury-Saha, Manami, Black, Chris, Watt, Andrew T., Marcusson, Eric G., Freier, Susan M., Edgington, Thomas S.
- FEBS letters 2011 v.585 no.4 pp. 671-676
- carcinoma, gene expression regulation, gene overexpression, genes, humans, hydrolysis, mice, non-coding RNA, transcriptome
- RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Σ RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Σ RNA/MALAT-1. These results support the hypothesis that Σ RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification.