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Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans

Lv, Xiaofei, Zhang, Yuan, Rao, Shaoqi, Su, Dongfang, Feng, Dan, Wang, Min, Li, Xinrui, Li, Dan, Guo, Honghui, Zuo, Xiaoyu, Xia, Min, Ouyang, Haimei, Ling, Wenhua, Qiu, Jian
Gene 2013 v.526 pp. 344-346
alleles, body mass index, coronary artery disease, gender, hypertension, models, myocardial infarction, patients, phosphorylase, risk, single nucleotide polymorphism
Studies focusing on the association of gene methylthioadenosine phosphorylase (MTAP) with the risk of coronary artery disease (CAD) and myocardial infarction (MI) are limited.In this study, we explored the effects of rs10118757 in MTAP gene on CAD and MI by performing association analysis in a Chinese Han population. rs10118757 was genotyped in 1007 CAD patients (including 338 MI patients) and 885 healthy controls. Allelic analysis showed that allele A of rs10118757 was associated with increased risk of CAD, with OR (95%CI)=1.193 (1.035–1.376), and P=0.015. After adjusted for age, BMI, gender, hypertension and smoking, rs10118757 was still significantly associated with CAD under additive and dominant models, with OR (95%CI)=1.252 (1.070–1.465), P=0.005, and OR (95%CI)=1.698 (1.168–2.467), P=0.006, respectively. Compared to additive model, dominant model may be the best-fitting model (P=6.63E−10 vs P=6.70E−10). As reported previously, rs10118757 was not associated with MI in the current study.Our study firstly reported that SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD.