PubAg

Main content area

Synthesis of selenium-containing polysaccharides and evaluation of antioxidant activity in vitro

Author:
Wang, Junlong, Zhao, Baotang, Wang, Xiaofang, Yao, Jian, Zhang, Ji
Source:
International journal of biological macromolecules 2012 v.51 no.5 pp. 987-991
ISSN:
0141-8130
Subject:
Artemisia sphaerocephala, antioxidant activity, antioxidants, bioavailability, carbon, catalysts, dietary supplements, humans, natural foods, nitric acid, nuclear magnetic resonance spectroscopy, polysaccharides, selenium, stable isotopes, temperature
Abstract:
Selenium (Se) is an essential trace element for human beings and many other forms of life. Organic Se from natural foods has higher bioavailability and is safer than inorganic Se species. In the present study, selenium-containing derivatives of Artemisia sphaerocephala polysaccharide with the highest Se content of 1703μg/g were synthesized using H₂SeO₃/HNO₃ and BaCl₂ as a catalyst. The effects of the ratio of HNO₃ concentration and reaction temperature were investigated. Results of Raman and ¹³C NMR spectroscopy indicated that C-6 substitution was predominant in selenized polysaccharide. A sharp decrease in Mw was observed in the selenized reaction due to the acid environment. The in vitro antioxidant results suggest that selenium-containing polysaccharide should be applied as a novel selenium source in dietary supplements, with potent antioxidant properties.
Agid:
997289