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Preparation and hydrolytic erosion of differently structured PLGA nanoparticles with chitosan modification

Author:
Ma, Fang Kui, Li, Jing, Kong, Ming, Liu, Ya, An, Yi, Chen, Xi Guang
Source:
International journal of biological macromolecules 2013 v.54 pp. 174-179
ISSN:
0141-8130
Subject:
biodegradability, chitosan, drugs, hydrolysis, nanoparticles, zeta potential
Abstract:
Two types of poly-lactic-co-glycolic acid (PLGA) based nanoparticles were prepared by surface modification (C-NPs) and homogeneous modification (G-NPs) with chitosan. The naked PLGA NPs were served as control. These nanoparticles all showed regularly spherical shape with mean diameters as 191.3±3.6nm, 211.9±13.2nm and 187.5±17.6nm for PLGA NPs, C-NPs and G-NPs, respectively. Their zeta potentials were −22.4±1.31mV, −8.7±0.45mV, −3.1±0.12mV, respectively. Both C-NPs (15.3% PLGA remained after 2 weeks) and G-NPs (3.7% PLGA remained after 2 weeks) had higher hydrolysis rate than PLGA NPs (18.4% PLGA remained after 6 weeks), with G-NPs showing the highest rate in hydrolysis due to the incorporation of chitosan and its self-assembled structure. Self-assembling properties and controllable biodegradability of G-NPs indicated that it could be a promising drug delivery carrier for tumor drug delivery.
Agid:
997375